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KMID : 0545120040140040852
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Journal of Microbiology and Biotechnology
2004 Volume.14 No. 4 p.852 ~ p.858
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Anticarcinogenic and Antigenotoxic Effects of Bacillus polyfermenticus
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Park EJ
Kim KT/Kim CJ/Kim CH/Paik HD
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Abstract
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The morbidity and mortality of colon cancer are increasing because of the westernization of food habit. Probiotics such as lactic acid bacteria (LAB) have been known to play an important role in retarding colon carcinogenesis by possibly influencing metabolic immunologic and protective functions in the colon. In this study we evaluated the effect of B. polyfermenticus SCD on N-methyl-N-nitro-N-nitrosoguanidine (MNNG) induced DNA damage in CHO-K1 cells and human lymphocytes and on proliferation of human colon cancer cell. Using the Comet assay to detect DNA damage we found that B. polyfermenticus SCD protected cells from the DNA damage induced by MNNG in CHO-K1 cells and in human lymphocytes. B. polyfermenticus SCD was also found to inhibit the growth of colon cancer cells in a dose-dependent manner detected by the MTT assay. These results indicate that B. polyfermenticus SCD has the potential to inhibit not only DNA damage induced by a carcinogen but also the proliferation of colon cancer cells.
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